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Advances in managing hepatocellular carcinoma
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《医学前沿(英文)》 2014年 第8卷 第2期 页码 175-189 doi: 10.1007/s11684-014-0332-4
Multiple modalities for treatment of hepatocellular carcinoma are available, depending on tumor size and number. Surgical resection remains the gold standard, so long as the residual liver function reserve is sufficient. In patients with advanced cirrhosis, liver transplantation is the preferred option, as these patients may not have adequate hepatic reserve after resection. Salvage liver transplantation has also become an option for a select few patients who recur after surgical resection. Ablative techniques have been used for palliation as well as to either completely destroy the tumor, act as an adjunct to resection, or downstage the tumor to meet Milan criteria such that a patient may be a candidate for liver transplantation. Radiofrequency ablation, microwave ablation, chemoembolization, radioembolization, and irreversible electroporation have all been used in this capacity. Currently, sorafenib is the only US Food and Drug Administration-approved chemotherapeutic for hepatocellular carcinoma. The efficacy of sorafenib, in combination with other agents, transarterial chemoembolization, and surgical resection is currently being investigated. Sunitinib and brivanib, tyrosine kinase inhibitors, have failed as potential first- or second-line options for chemotherapy. Bevacizumab in combination with erlotinib is also currently being studied. Final analysis for ramucirumab and axitinib are pending. Tivantinib, a selective mesenchymal-epithelial transition factor (MET) inhibitor, is also undergoing clinical trials for efficacy in MET-high tumors. This review serves to emphasize the current and new technologies emerging in the treatment of hepatocellular carcinoma.
关键词: hepatocellular carcinoma radiofrequency ablation microwave ablation chemoembolization radioembolization sorafenib irreversible electroporation
Towards the optimization of management of hepatocellular carcinoma
Xi Feng, Madhava Pai, Malkhaz Mizandari, Tinatin Chikovani, Duncan Spalding, Long Jiao, Nagy Habib
《医学前沿(英文)》 2011年 第5卷 第3期 页码 271-276 doi: 10.1007/s11684-011-0148-4
关键词: management hepatocellular carcinoma (HCC) radiofrequency (RF) ablation laparoscopic liver resection stem cell intravascular RF ablation endobiliary RF ablation
State-of-the-art of intelligent minimally invasive surgical robots
Masakatsu G. Fujie, Bo Zhang
《医学前沿(英文)》 2020年 第14卷 第4期 页码 404-416 doi: 10.1007/s11684-020-0743-3
关键词: robot history medical robot surgical robot radiofrequency ablation organ model
Outcome of Stretta radiofrequency and fundoplication for GERD-related severe asthmatic symptoms
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《医学前沿(英文)》 2015年 第9卷 第4期 页码 437-443 doi: 10.1007/s11684-015-0422-y
This study aimed to investigate the outcome of treatment with Stretta radiofrequency (SRF) or laparoscopic Nissen fundoplication (LNF). A total of 137 gastroesophageal reflux disease (GERD) patients with severe asthmatic symptoms who responded inadequately to medical treatment for asthma were investigated. The patients were followed up 1 year and 5 years after SRF (n = 82) or LNF (n = 55) treatment. A questionnaire covering 29 related symptoms and medication use was employed. Digestive, respiratory, and ear-nose-throat (ENT) symptom scores significantly decreased after antireflux treatment. Symptom scores respectively changed from 17.2±10.1, 31.9±6.6, and 21.1±11.8 to 5.0±6.2, 11.5±10.2, and 6.3±6.8 at 1 year and to 5.6±6.5, 13.1±10.1, and 7.8±7.2 at 5 years (P <0.001). The outcome of LNF was significantly better than that of SRF in terms of digestive (P <0.001, P = 0.001), respiratory (P = 0.006, P = 0.001), and ENT symptoms (P = 0.006, P = 0.003) at both 1 year and 5 years. SRF and LNF were both effective against the digestive symptoms of GERD as well as GERD-related severe asthmatic and ENT symptoms, with better outcomes exhibited by the LNF group. Severe asthmatic symptoms and GERD were closely associated, and this finding warrants further study.
关键词: asthma gastroesophageal reflux Stretta radiofrequency laparoscopic Nissen fundoplication
Laser ablation of block copolymers with hydrogen-bonded azobenzene derivatives
Jintang Huang, Youju Huang, Si Wu
《化学科学与工程前沿(英文)》 2018年 第12卷 第3期 页码 450-456 doi: 10.1007/s11705-018-1735-6
Supramolecular assemblies (PS-b-P4VP(AzoR)) are fabricated by hydrogen-bonding azobenzene derivatives (AzoR) to poly(4-vinyl pyridine) blocks of polystyrene-block-poly(4-vinyl pyridine) (PS-b-P4VP). PS-b-P4VP(AzoR) forms phase separated nanostructures with a period of ~75–105 nm. A second length scale structure with a period of 2 µm is fabricated on phase separated PS-b-P4VP(AzoR) by laser interference ablation. Both the concentration and the substituent of AzoR in PS-b-P4VP(AzoR) affect the laser ablation process. The laser ablation threshold of PS-b-P4VP(AzoR) decreases as the concentration of AzoR increases. In PS-b-P4VP(AzoR) with different substituents (R= CN, H, and CH3), ablation thresholds follow the trend: PS-b-P4VP(AzoCN)<PS-b-P4VP(AzoCH3)<PS-b-P4VP(AzoH). This result indicates that the electron donor group (CH3) and the electron acceptor group (CN) can lower the ablation threshold of PS-b-P4VP(AzoR).
关键词: laser ablation block copolymers hydrogen-bond azobenzene derivatives supramolecular assembly
High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience
Lian ZHANG, Zhi-Biao WANG
《医学前沿(英文)》 2010年 第4卷 第3期 页码 294-302 doi: 10.1007/s11684-010-0092-8
关键词: high-intensity focused ultrasound (HIFU) ultrasound imaging-guided HIFU (USgHIFU) magnetic resonance imaging-guided HIFU (MRgHIFU)
Jianpeng Liu, Xinhua Chen, Shusen Zheng
《医学前沿(英文)》 2021年 第15卷 第2期 页码 170-177 doi: 10.1007/s11684-020-0747-z
关键词: nanosecond pulsed electric fields (nsPEF) hepatocellular carcinoma (HCC) immune response recurrence metastasis
Ling-Yan XU PhD, Xin-Ran MA PhD, Xiao-Ying LI PhD, MD, Shu WANG PhD, Guang NING PhD, MD, Jie-Li LI PhD, Jian-Ming XU PhD,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 229-234 doi: 10.1007/s11684-010-0028-3
关键词: steroid receptor coactivator-3 white adipose tissue brown adipose tissue obesity adipocytes energy expenditure
用高光谱发光法研究Cu(Inx,Ga1–x)Se2 (CIGS)模块中由P1引起的功率损耗的成因 Article
César Omar Ramírez Quiroz, Laura-Isabelle Dion-Bertrand, Christoph J. Brabec, Joachim Müller, Kay Orgassa
《工程(英文)》 2020年 第6卷 第12期 页码 1395-1402 doi: 10.1016/j.eng.2019.12.019
在本文中,我们利用了高光谱高分辨率光致发光映射技术,这是一个强大的工具,可用于选择和优化在Cu(Inx,Ga1-x)Se2(CIGS)模块上对子电池进行图案化互连的激光烧蚀工艺。通过这种方式,我们可以完成对消融区域附近材料降解的深度监测以及对潜在机制的识别。具体而言,通过分析在CIGS沉积之前烧蚀的标准P1图案线,我们发现了沿着下部的钼槽边缘的异常发射猝灭效应。通过扫描电子显微镜(SEM)比较了P1边缘的横截面的形貌,我们进一步合理化产生这种效应的起因,但无法用厚度变化解释光发射的减少。我们还研究了激光诱导对CIGS沉积后的P1图案线带来的损伤。然后,我们首次记录了短距离损坏区域,该区域与在激光路径上应用的光学孔径无关。我们的发现能更好地理解P1引起的功率损耗,并为改进与行业相关的模块互连方案提供了新的见解。
关键词: Cu(Inx Ga1–x)Se2 电池到模块的效率差距 由P1引起的功率损耗 高光谱光致发光 激光烧蚀短程热效应
标题 作者 时间 类型 操作
Towards the optimization of management of hepatocellular carcinoma
Xi Feng, Madhava Pai, Malkhaz Mizandari, Tinatin Chikovani, Duncan Spalding, Long Jiao, Nagy Habib
期刊论文
State-of-the-art of intelligent minimally invasive surgical robots
Masakatsu G. Fujie, Bo Zhang
期刊论文
Outcome of Stretta radiofrequency and fundoplication for GERD-related severe asthmatic symptoms
null
期刊论文
Laser ablation of block copolymers with hydrogen-bonded azobenzene derivatives
Jintang Huang, Youju Huang, Si Wu
期刊论文
High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience
Lian ZHANG, Zhi-Biao WANG
期刊论文
Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric
Jianpeng Liu, Xinhua Chen, Shusen Zheng
期刊论文
Ablation of steroid receptor coactivator-3 in mice impairs adipogenesis and enhances energy expenditure
Ling-Yan XU PhD, Xin-Ran MA PhD, Xiao-Ying LI PhD, MD, Shu WANG PhD, Guang NING PhD, MD, Jie-Li LI PhD, Jian-Ming XU PhD,
期刊论文